Myotatic, Kinesthetic and Vestibular Mechanisms

نویسنده

  • Don C. Higgins
چکیده

This monograph is a collection of papers presented by The Ciba Foundation Study Group on Antilymphocytic Serum which included such noted immunologists as Humphrey, Medawar, Gell, and Gowans who joined with other workers in presenting clinical and experimental studies with this material. The auspicious tone that apparently pervaded the meeting is set by Humphrey's opening remarks that antilymphocytic serum might be regarded as analogous to Ehrlich's "magic bullet" in suppressing the immune response and by a comment in the closing discussion about the urgency of its use in patients undergoing transplantation. However, the experimental findings presented hardly justify this optimism. Immediately after the introduction, the expected sequence never materializes and the reader is abruptly faced with a mass of findings in patients treated with antilymphocytic globulin while undergoing renal transplanta-tion at the University of Colorado. The data seem interminable and could benefit by consolidation. More importantly, the investigators admit that it was not tested alone but always in conjunction with other well-known forms of immune suppression. Experimental data in mice, dogs, and primates follow. As is noted in the discussion, however, disagreement is not limited to theories alone but also extends to such critical facts as the effect of antilymphocytic serum on size and cellularity of the chief antibody producing organs. The sections dealing with lymphocyte blast transformation, other in vivo and in vitro properties of antilymphocytic serum and its postulated mode of action contain basic concepts that should have logically preceded the clinical presentations. The ideas and data are clearly presented and repay careful reading. There is a concluding discussion by all the participants highlighted by a discourse by Medawar on possible hypotheses for the roles of antilym-phocytic serum in suppressing homograft rejection. Five theories are considered with his evaluation of the merit of each. For the investigator who may be interested in the use of antilymphocytic serum either for studying delayed hypersensitivity, or for prolonging graft survival, the book should prove invaluable since it details the status of work in this field up to January, 1967, including many previously unreported problems in its production. This third and final Ciba Foundation Symposium of a series concerned with receptor function, chaired by 0. Lowenstein, deals with the special problems of postural control mediated through the actions of spinal and brainstem centers. Approximately one fifth of the volume is devoted to muscle and joint sensors and their known central actions, while …

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عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 40  شماره 

صفحات  -

تاریخ انتشار 1968